Entourage Effect

Cannabis researchers have identified more than 480 components in cannabis, including 66 compounds unique to the cannabis plant alone . Scientists have yet to determine exactly how these chemical components work together to produce different reactions. One concept, termed the “entourage effect,” theorizes that some cannabis compounds, which have no effect in isolation, affect the human body only when combined with other components.

Before the entourage effect gained prominence in medical cannabis circles, many researchers discussed the concept of synergy in herbal medicines and dietary supplements. For components within an herbal medicine to achieve synergy, the effects of two or more components must become magnified when combined. Synergisms is said to explain why vitamins in isolation are less beneficial than eating fruits and vegetables that contain a wide variety of vitamins and antioxidants.

Leading cannabis researchers believe that the entourage effect explains why cannabis can be so effective when treating certain conditions while formulations of only THC or CBD medications may only achieve limited success in some patients. Evidence suggests that although certain cannabinoids may appear to be inert, they may produce tangible benefits when mixed with other compounds.

While the effect of CBD on THC is the most notable illustration of the entourage effect, research also indicates that cannabinoids and terpenes may also combine to achieve greater therapeutic advantages. Studies indicate that certain terpenes impact the blood-brain barrier. Terpenes, the molecules responsible for marijuana’s smell, have been shown to block some cannabinoid receptor sites in the brain while promoting cannabinoid binding in others.The terpene myrcene, for example, can reduce resistance in the blood-brain barrier, enabling easier passage of other beneficial chemicals. Pinene helps counteract compromised cognition and memory caused by THC. Terpenes are believed to affect many aspects of nearly 500 different cannabis components.

Mr. Natural encourage’s you to explore and find the cannabis profile that works best for you.